There are many different supplements on the market that claim to be able to help with a variety of health concerns. NMN supplement is a relatively new supplement that is gaining popularity for its potential to help reverse the effects of aging. But can NMN really live up to the hype?
What you will learn
- What is NMN Supplement?
- What are the Benefits of NMN Supplements?
- Can NMN reverse aging?
- The 10 Best NMN Supplements in the Market Today
- Best NMN Supplement for Overall Value : Renue By Science LIPO NMN – Powdered Liposomal NMN
- Best NMN Supplement for absorption: Fast Dissolve NMNs™ Tablets
- Best NMN Supplement for NAD+ generation : Life Extension NAD+ Cell Regenerator
- Best NMN Supplement to improve overall well-being : Tru Niagen 300mg
- Best NMN Supplement to combine NR and Resveratrol : Infiniwell NMN – Healthy Aging Support
- Best NMN Supplement of ingredients : Wellabs NMN Supplement
- Best NMN Supplement for intranasal : Pure NAD+ MICROMIST Spray
- Best NMN Supplement for sublingual use : Renue By Science NMN w/ Resveratrol LIPO Gel
- Best NMN Supplement combined NAD+ and NMN : LIPO NAD+ Complete – Powdered Liposomal
- Best NMN Supplement for the cheapest cost : Pure NMN Powder
- How NMN Works?The Science Behind NMN
- Is it better to take NAD or NMN?
- NMN Vs. NR
- How Can NMN Absorption Be Improved?
- How to Use the Best NMN Supplements for the Best Results
- Which type of NMN is the best?
- What is the optimal NMN dose?
- When should you use NMN supplements?
- Is NMN need to be refrigerated?
- How to find the best NMN supplement?
- List of David Sinclair Supplements
- Side Effects of NMN Supplements
What is NMN Supplement?
NMN is a nicotinamide mononucleotide, which is a nucleotide that occurs naturally in the body and plays an important role in energy production. Nicotinamide mononucleotide supplements have been shown to increase levels of NAD+ in the body, which is important for energy production, cell repair, and other important functions. NAD+ levels decline with age, so supplementing with NMN has the potential to reverse some of the effects of aging.
There is still much research to be done on NMN supplements and their potential benefits, but they show promise as a way to slow down or even reverse some of the effects of aging. If you’re interested in trying an NMN supplement, be sure to talk to your doctor first to see if it’s right for you.
What are the Benefits of NMN Supplements?
NMN supplements have become increasingly popular as people look for ways to slow down the aging process. There is some scientific evidence to suggest that NMN may be beneficial for overall health and longevity. NMN supplements are thought to offer a number of potential health benefits, including:
1. Slowing down the aging process: NMN has been shown to slow down the aging process in animals. One study found that NMN supplementation increased the lifespan of mice by up to 25%.
2. Improving metabolism: NMN has been shown to improve metabolism and blood sugar control in animals. It is thought that NMN may help to increase insulin sensitivity and reduce inflammation.
3. Enhancing brain function: NMN has been shown to improve cognitive function and protect against age-related brain diseases in animals. It is believed that NMN may help to preserve brain function as we age.
4. Strengthening bones: NMN has been shown to improve bone density and reduce the risk of osteoporosis in animals.
5. Improving cardiovascular health: NMN has been shown to reduce cholesterol levels and blood pressure in animals. It is thought that NMN may help to protect against heart disease.
Other health benefits of NMN include:
- Enhances insulin sensitivity
- Diabetes, fatty liver disease, and obesity are all prevented
- Rejuvenates mice
- Promotes cognition in Alzheimer’s patients
- It protects against neurodegeneration
- Enhances memory
- Fat mass is reduced.
- Increases lean muscle mass
- Boost immune function
- Microbe resistance and immunodeficiency
- Provides the advantages of calorie restriction
- Improving Human Performance
- Potentially beneficial in the treatment of COVID
- Restores fertility
- Enhances mitochondrial health
- Promotes DNA repair
Can NMN reverse aging?
The short answer is that we don’t know yet. NMN is a new supplement and there is not enough research to say definitively whether or not it can help to reverse the aging process. However, there is some preliminary evidence that NMN may have anti-aging properties.
NMN is a form of nicotinamide mononucleotide, a nucleotide that occurs naturally in our cells. Nucleotides are the building blocks of DNA and play an important role in many cellular processes. NMN supplements have been shown to increase levels of nicotinamide adenine dinucleotide (NAD+) in cells. NAD+ is a coenzyme that is involved in energy metabolism, cell repair, and other important cellular processes.
As we age, our levels of NAD+ decline. This decline has been linked with age-related diseases such as Alzheimer’s and Parkinson’s, as well as with the general deterioration of our cells. Some scientists believe that boosting NAD+ levels with NMN supplements could help to reverse these age-related changes and improve overall health.
However, it’s important to keep in mind that this is still a very new area of research and it’s not yet clear if supplements like NMN can actually reverse the aging process.NMN has been shown to be a powerful antioxidant and stimulates cellular regeneration. In 2013 study, researchers David Sinclair and his colleagues found that by using NMN to help regenerate insulin-producing cells, a cause of aging that is potentially reversible.
The 10 Best NMN Supplements in the Market Today
When it comes to NMN supplements, there are a lot of options out there. So, how do you know which one is the best? In this blog post, we’ll give you a rundown of the best NMN supplements in the market today.
We’ve looked at a variety of factors, including potency, price, and customer reviews, to come up with this list. So, without further ado, here are the best NMN supplements in the market today:
LIPO NMN by Renue By Science ( Alive By Science), a leading anti-aging company, is undoubtedly the first product on this list. Renue By Science offers a variety of NAD+ precursor supplements. The company is best known for its liposomal technology, which encapsulates the ingredients in tiny liposomal-based substances and delivers them directly to the cells. Liposomes are made up of phospholipids, which are the basic components of cell membranes. This increases the bioavailability of the ingredient by allowing it to be delivered to the cell more easily than with traditional methods.
LIPO NMN comes in a bottle with 90 capsules, each containing 250 mg of highly concentrated powdered liposomal NMN. The bottle will set you back $95.94. LIPO NMN is an excellent choice for increasing NAD+ levels in the body since NMN is the most efficient of the NAD+ precursors outlined above, and liposomal technology makes it highly bioavailable. Renue by Science goods are GMP certified, and it is the only NMN firm that tests the finished product independently and labels each bottle with a batch number for verification. Third-party lab certificates are included on the product page, certifying that the product is free of contaminants, includes the amount of ingredients listed on the label, and meets purity and strength standards.
We awarded Renue by Science Liposomal NMN our Overall Best NMN supplement for 2022.
These tablets can be chewed or swallowed (under the tongue). In either case, a portion of the NMN is absorbed straight into the bloodstream and easily available to cells throughout the body, as opposed to being nearly completely digested in the stomach as capsules are (r).
For fast absorption, the dissolving method is the best. Each serving contains 250 mg.If you want something that works quickly, this NMN supplement tablet is a good choice because it bypasses digestion. They have a fast absorption rate and can reach systemic circulation in minutes, resulting in a noticeable effect. So whether you need a short boost before a quick workout or you need to focus on mental activities rapidly, these supplements can help.
This supplement from Life Extension is one of the most potent NMN supplements in the market. It contains 250 mg of NMN per serving, and is designed to support healthy NAD+ levels.
This NIAGEN® nicotinamide riboside formula enhances the generation of NAD+, a coenzyme that supports cellular metabolism and boosts cellular energy production.
NAD+ Cell RegeneratorTM contains 300 mg of NIAGEN®, the first commercially available version of nicotinamide riboside, to help battle weariness at the cellular level and preserve youthful levels of NAD+.
NIAGEN® protects against cellular aging by promoting the generation of nicotinamide adenine dinucleotide (or NAD+).
The Life Extension NAD+ Cell Regenerator is also fairly priced, and comes with a money-back guarantee. So, if you’re looking for a high-quality NMN supplement, this is a great option.
Tru Niagen 300mg contains daily recommended amount of NAD+ booster in one easy-to-swallow capsule. NAD+ levels naturally fall as you become older. Tru Niagen helps to preserve general health and well-being by supporting cellular function and metabolism.
With a single pill containing one active component, Tru Niagen supports numerous bodily systems. This simplifies your supplement stack and reduces the possibility of side effects. The FDA has acknowledged its safety, and numerous clinical studies have demonstrated its effectiveness.
Infiniwell has long been a pioneer in the dietary supplement business, offering consumers high-quality products with unmatched results. This helped Infiniwell establish a solid reputation. Infiniwell is now providing you the most innovative and high-quality supplements available. Supplements for healthy aging, post-exercise recovery, and mood support are available from Infiniwell, and new items are released on a regular basis.
NMN has been examined for its ability to improve cell health. The combination of NR and Resveratrol aids in the production of NAD+, which aids in the maintenance of healthy DNA cell structure. This is critical for healthy aging.
Wellab’s NMN is an all natural anti-aging supplement that is designed to treat some age-related conditions. It is a powder supplement that is made up of some of the most effective and powerful antioxidants. These antioxidants can slow down the aging process and help you look years younger. It is made with a combination of ingredients that are proven to be very effective in making you look younger and healthier.
Renue By Science specializes on NAD boosters, as previously said. Their priorities have been to use cutting-edge delivery technologies and to set market-leading pricing. Intranasal NAD, like sublingual and liposomal preparations, may avoid stomach acid and liver degradation.
NMN has a systemic, all-over-the-body action. Intranasal technology, on the other hand, can work to help the brain by bypassing the blood-brain barrier. Other types of NMN do not have this feature. Intranasal NAD, according to researchers, will enhance NAD levels in the brain more than any other delivery route. Intranasal administration activates swiftly, targets the brain, and decreases potential adverse effects by requiring a smaller dosage.
Renue by Science conducts four rounds of pharmaceutical-grade purity testing on all of its goods. A certificate of analysis (CoA) guaranteeing purity and safety is included with every product.
The NMN with Resveratrol LIPO Gel is designed to raise your body’s NAD+ levels by delivering the most effective amount of NMN via nanoscale liposomes.
The liposomes shield the NMN from breakdown in the digestive system’s hostile environment and carry it to the cells and tissues directly. Because of the long-term release, relatively little NMN is converted to nicotinamide.
This eliminates the risk of over-methylation or sirtuin inhibition, which can occur when using normal (non-liposomal) capsules.
These Gels are an excellent choice for persons who have difficulty swallowing tablets but still wish to benefit from the liposomal solutions. It only requires two pumps under the tongue and 30-60 seconds to absorb before eating.
To preserve and combine NMN and NAD+ from breaking down in digestive enzymes in your stomach, this product from Alive By Science NMN uses only liposomal NAD booster and NMN in powdered liposomal supplement form. The liposomes in Alive By Science boost bioavailability in the body, allowing more liposomal NMN products and NAD+ to be absorbed.
The combination of these Alive By Science nutriop NMN supplements includes liposomal NMN capsules, which allow NAD+ to pass the blood-brain barrier for delivery to brain cells as a nootropics depot NMN dosage while also successfully reaching other regions of the body.
Alive By Science and liposomal technology have undergone comprehensive testing and are free of contaminants, having been triple-lab tested.
While the Alive By Science supplement has been carefully verified for quality, there appear to be some problems with the packing facility. Some customers have complained that their supplements arrived with cracked or damaged capsules, rendering them unfit for consumption.
Renue By Science is on the list once more, this time for their bulk NMN powder. For a rapid energy boost, sublingual is the preferred administration technique. as well as the ability to truly feel your supplement Sublingual delivery also increases the amount of NMN in your circulation, resulting in more systemic effects.
NMN supplementation is costly, even though costs have reduced dramatically in recent years. For around the best price $117.95, you can get 100 grams Pure Crystalline NMN Powder.Pharmaceutical-grade purity testing and a certificate of analysis (CoA) for safety are included, as with other Renue by Science goods.
How NMN Works?The Science Behind NMN
NMN is a supplement that has been shown to have anti-aging properties in both animal and human studies. It is a precursor to nicotinamide adenine dinucleotide (NAD+), which is a key molecule in energy production and cellular repair. NAD+ levels decline with age, and this has been linked to the age-related decline in function. Supplementing with NMN has been shown to increase NAD+ levels, and this may help to reverse some of the age-related decline in function.
There is still more research needed to determine the exact mechanisms by which NMN works, as well as its long-term safety. However, the available evidence suggests that NMN may be a promising anti-aging supplement that could help to restore some youthful function.
Environmental factors such as pollution, radiation, and imperfect DNA replication caused by aging cause DNA damage as we age. To repair this damage, almost all cells have molecular engines that utilise NAD+ and energy metabolism. According to new research and clinical studies, Nicotinamide Mononucleotide (NMN) enhances NAD and aids in the restoration of organ systems to a healthy condition.
Reduced amounts of Nicotinamide Mononucleotide, NAD+, and sirtuins disrupt the regenerative process, leading in premature aging. The greatest NMN supplements can be used to help boost this regeneration capability. If you have low NAD levels, you may want to start taking nicotinamide mononucleotide as a supplement.
The best NMN supplements are divided into several categories, each with its own set of advantages and delivery methods.
This is the most affordable NMN supplement available. Unfortunately, the body finds it the most difficult to absorb.
When powdered liposomal NMN (lipo NMN) and NR enter the stomach and digestive tract unprotected (through a capsule, for example), stomach acid breaks it down into NAM (nicotinamide), which prevents it from reaching the tissues and cells that need it.
Increasing your NMN powder dosage will not help you get over this, since it will result in an excess of NAM, which is harmful to your health.
Sublingual NMN is a Nicotinamide Mononucleotide supplement that is dissolved under the tongue, bypassing the liver and allowing more of it to enter the circulation. Sublingual NMN is a more costly version of NMN, however this is because it releases NMN quickly, providing you a swift energy boost. For optimal effect, we recommend bulk sublingual NMN powder and pharmaceutical-grade NMN supplements.
Because it may cross the blood-brain barrier, intranasal NMN is one of the finest methods for delivering NMN to the brain. It has fewer adverse effects, needs lower dosages, and has shown good increases in NMN in the brain.
Nasal spray bottles are the most prevalent kind of intranasal NMN.
Liposomes are fatty shells that contain the Nicotinamide Mononucleotide (NMN). Liposomal NMN supplements are taken orally as capsules, and the inclusion of liposomes prevents the NMN from degrading in the stomach, allowing more of it to be absorbed by the body.
Liposomes also aid in the persistent release of the NMN, resulting in a steady rise in NAD+ over the course of 24 hours.
Is it better to take NAD or NMN?
Nicotinamide mononucleotide is abbreviated as NMN. It is a precursor of nicotinamide adenine dinucleotide, a coenzyme in the body (NAD). NMN is a chemical that stimulates your body to produce NAD, which can improve the efficiency with which your body’s cells perform.
By helping your cells to perform more efficiently, NAD supplementation can deliver anti-aging advantages such as improved cognition and a more youthful look. According to some research, it improves athletic performance by boosting your VO2 max after only a brief time of usage. Others associate it with decreased insulin resistance, which can result in anything from a lower risk of diabetes to a slimmer waistline.
It is preferable to consume NMN, as it is a direct precursor of NAD+. Second, nicotinamide has the potential to suppress sirtuins, which are crucial enzymes that serve to protect the DNA and epigenome. This is because NAD+ is transformed into NAM in order for the sirtuins to be “activated.”
NMN Vs. NR
Both nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR or Niagen) serve the same purpose in the body: to create NAD+. However, during the body’s conversion of these molecules to NAD+, nicotinamide riboside naturally converts into NMN, and the two work together to build up NAD+ via Nuclear Magnetic Resonance (NMR).
The only difference between the two is their size. The bigger of the two molecules, Nicotinamide Mononucleotide (NMN), must be broken down to fit inside a cell.
Cellular transporters have a role in this. These are essentially “doorways” into cells that allow molecules to enter without having to undergo any chemical transformations.
There are presently no studies that demonstrate that one is superior to the other. Some experts, however, believe that Nicotinamide Mononucleotide (NMN) is a step ahead of nicotinamide riboside. It’s just another stage in the process of forming NAD+.
To make NMN, NR must be phosphorylated (a chemical reaction that adds a phosphoryl group to an organic molecule). Your body will only begin to manufacture NAD+ after that.
NMN Has More Effects
Because Nicotinamide Mononucleotide (NMN) is more digested than NR, it has been found to help with a variety of aging symptoms that NR has not.
It may also be useful in the treatment of Alzheimer’s disease. In the brain, NMN helps to heal cellular damage. However, because supporting research are still in the early stages, there is no solid confirmation one way or the other.
In the circulation, NR is fragile and rapidly degrades into vitamin B3. This means that a considerable amount of NR gets broken down before it can be absorbed where it is needed.
A thorough review of comparable studies suggests that NMN has slightly greater and more diversified effects than NR. Greater insulin sensitivity, increased bone density, improved mitochondrial activity, and a stronger immune system are among the benefits.
Improvements in aging and symptoms from age-related disorders have been found more frequently in NMN than in NR.
Natural Compound With Insulin Resistance Potential
Nicotinamide Mononucleotide (NMN) has been proven in studies to improve insulin sensitivity and signaling. Insulin resistance grows with age and with age-related disorders — the more insulin resistant our tissues are, the faster they age.
Insulin resistance is also linked to type 2 diabetes, making NMN appealing to diabetics and prediabetics.
How Can NMN Absorption Be Improved?
One approach for increasing absorption is through the delivery system. However, this is not the only option. While the research is still in its early stages, some have observed that anything high in a flavonoid called apigenin can boost NMN absorption. Apigenin-rich foods include parsley, chamomile, celery, and artichokes.
How to Use the Best NMN Supplements for the Best Results
If you’re looking for the best way to supplement with NMN, you’ve come to the right place. In this article, we’ll guide you through everything you need to know in order to get the most out of your NMN supplements.
NMN is a powerful anti-aging compound that has been shown to reverse many of the effects of aging in animal studies. However, human studies are still in their early stages. Nevertheless, there is promising evidence that NMN supplementation can improve some of the key markers of aging, such as DNA damage and inflammation.
The best way to take NMN supplements is by mouth, either in capsule form or as a powder that can be mixed with water or another beverage. The recommended dosage is 250-1000 mg per day.
When it comes to choosing the right NMN supplement, it’s important to choose a product that is pure, potent, and free of contaminants. We recommend only purchasing supplements from reputable companies that offer third-party lab testing.
Which type of NMN is the best?
Again, as more individuals turn to alternative supplements, research into the optimal manner to give NMN is progressing.
One of the issues that consumers typically encounter while experimenting with different supplements is the supplement’s bioavailability. This is because there is always a danger of active component breakdown along the road to the GI tract when NMN is taken orally. As a result, the supplement’s potency and efficacy are reduced.
Liposomal NMN ensures that the active components are preserved in a phospholipid capsule. Because phospholipids may easily permeate cell membranes, liposomal NMN active components reach the target locations, and overall biodistribution and absorption are good, resulting in optimal advantages.
What is the optimal NMN dose?
The optimal NMN dosage will differ for each individual. It’s also difficult to quantify the precise variations in absorption across the various NMN administration modalities. We recommend starting with a modest dose (500 mg or less) and gradually increasing. For the first few weeks, it may be best to get a 500 mg dosage with a serving size of two tablets (250 mg each) and just take one pill. That will be a wise approach to assess its effectiveness while saving you money.
When should you use NMN supplements?
While further study is needed, it appears that the best time to take NMN is in the morning since it will keep your energy levels up throughout the day, making you feel productive and enthusiastic.
Is NMN need to be refrigerated?
The answer is Yes if you are combining into a liquid solution. This will guarantee that the NMN supplement retains its full power for a longer period of time.
How to find the best NMN supplement?
So, where do you look for the greatest NMN supplement? And double-check that the supplement is a reputable, high-quality product?
You’d have to pay attention to the following factors:
The NMN company has a team of highly regarded scientific consultants
Make sure your NMN supplement comes from a company with top longevity experts on its advisory board and collaborates with renowned aging scientists as scientific consultants.
You may look up these researchers on Google to discover if they are affiliated with a university or lab, and see how many studies they have published on PubMed.
You’ll be able to verify that they’re active, well-respected scientists this way.
Be cautious of NMN promises of “excellent purity”
Purchase a supplement that is high-purity (carrying more than 99 percent NMN), not one that has been contaminated with other compounds.
However, be wary of NMN pills that claim to be “99 percent pure.” Purity is frequently assessed subjectively rather than objectively.
The “purity” of a supplement is frequently determined by comparing it to other supplements that are less pure. This allows one to claim extremely high “purities.”
To determine the true purity, however, one must compute the purity objectively by testing the absolute purity of the supplement itself.
Alternatively, when comparing NMN to a gold standard of NMN, the purity of the brand should be greater than 100 percent pure (e.g. 101 percent purity). This indicates that the NMN is purer than gold.
Make sure it’s a new-generation NMN that’s stable
Did you realize that not all NMNs are created equal?
The NMN of newer generations is more stable. NMN is a fragile molecule that can be transformed to nicotinamide when exposed to water molecules (NAM).
The surrounding water molecules and the arrangement of the NMN with other surrounding NMN molecules play a big role in NMN stability. The polarity of water molecules (different electric charges on opposite sides) might affect the electron configuration of the NMN molecule, resulting in decreased stability.
The destabilizing interaction between water molecules in the product and water from the air is less severe in NMN molecules that are more neatly ordered and compactly arranged. Furthermore, by reducing water content, more “high-density” NMN is produced, which enhances stability.
Even more crystalline NMN (and NMN derivatives) exist, requiring special NMN molecule organization for which David Sinclair’s business MetroBiotech has filed patents. Take, for instance, this patent. This, though, is probably excessive.
NMN testing by a third-party lab
Check to see if the NMN supplement vendor collaborated with third-party labs to test the supplement for impurities like:
Heavy metal is a genre of music that is characterized by (e.g. lead, arsenic, cadmium and mercury)
Bacteria are microorganisms that live in the (e.g. E coli, S aureus, Salmonella)
Mold and yeast
Toxic substances (e.g. toluene, xylenes, trichloroethylene, isopropyl alcohol, ethylene oxide, ethyl ether, acetone, benzene, chloroform, acetonitrile, etc). Toluene is a significant contaminant that must be monitored.
Be aware that some firms only test for heavy metals and not for microorganisms such as yeast and bacteria, or that some companies only test for microorganisms and not for heavy metals.
Make sure your NMN supplement has been third-party tested for purity and safety by independent testing labs. Many NMN supplement providers use testing companies that are less well-known and recognized.
The NMN has been made correctly
Ensure that your NMN supplement is made in a facility that follows GMP (Good Manufacturing Practices) and the most recent ISO standards.
In addition, the NMN production process must be cutting-edge.
This means, for example, that the pH and water content must be tightly regulated during the manufacturing process. A overly acidic or alkaline atmosphere will disrupt the NMN crystals’ electric equilibrium. Furthermore, the water concentration of the crystals is regulated throughout manufacture, which increases the NMN’s stability even further.
It is critical to employ novel-generation NMN composed of spherical crystals in this technique, which has higher bulk density and fluidity, to avoid unstable doses caused by dust in the manufacturing process.
List of David Sinclair Supplements
Keep in mind that Dr. David Sinclair has made it a point not to advertise or endorse any supplement items to date. This list was developed from interviews and publications in which Professor David Sinclair discusses supplements he uses.
We don’t know if he still takes these supplements or if he takes any other supplements that aren’t on this list.
For example, on page 304 of his book Lifespan, he discusses taking NMN and resveratrol every morning, typically combined with his yogurt.
The following is a summary list:
- Nicotinamide Mononucleotide (NMN) 1g in the morning
- 1g of resveratrol every day in the morning
- Metformin (prescription drug) 1 gram per day (500 mg in the morning and 500 mg at night)
- 1 mg spermidine each day in the morning
- Quercetin and fisetin, 500 mg twice day, in the morning
- Vitamin D3
- Vitamin K2
- Due to a family history of cardiovascular disease, he has been taking a statin (prescription medicine) since his early twenties.
- Aspirin at a low dosage of 83 mg per day
- Alpha Lipoic Acid (ALA)
- Q10 coenzyme
Side Effects of NMN Supplements
NMN has been widely studied by scientists.When taken in large doses, several NAD booster supplements have been linked to negative side effects such as diarrhoea,nausea, flushing, indigestion and stomach discomfort . People who took part in tests with NMN supplements, on the other hand, reported no noticeable side effects at dosages of 500mg and higher.
Harvard Professor Dr. David Sinclair, who was named one of Time Magazine’s most influential people in the world, has been using NMN supplements with others in the aging sector for years.He claimed to take as much as one gram of NMN every day with only an occasional upset stomach to show for his pains, but his experiences refer only to him. When this happens, NMN breaks down into Nicotinamide, which is toxic to your body. As a result, it’s critical to keep your NMN in a chilly environment, preferably in the fridge.
In terms of clinical trials, a human research in Japan revealed no negative side effects at levels up to 500mg, whereas another study on endurance found problems at doses up to 1200mg. Although more research is needed, there are currently no substantial safety concerns about NMN supplementation.
The abundance of cheap and false imitations on the market is the largest safety risk. There are products on the market that make similar promises for a fraction of the cost. Many of these aren’t pure NMN, but have been supplemented with other substances. If the maker has not been transparent about what’s inside, there could be safety concerns. To be safe, stick to well-known brands that have been independently vetted.
There is no doubt that NMN supplements hold a lot of promise when it comes to reversing the aging process. However, as with any supplement, it is important to speak to your doctor before starting to take them. This is especially true if you have any existing health conditions or are taking any other medication. That being said, if you are healthy and looking for a way to help slow down the aging process, NMN supplements could be worth considering.